Preterm birth (PTB) remains the leading cause of neonatal mortality and long term disability throughout the developed and developing world.  A growing body of evidence suggests that 1st trimester administration of low dose aspirin can reduce the rate of PTB substantially. This prospective, randomized, placebo-controlled, double-blinded, multi-center clinical trial will examine whether low dose aspirin initiated between 6 0/7 weeks- 12 6/7 weeks gestation reduces the risk of PTB.

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